Most of the natural products isolated at present are heterocyclic compounds, so heterocyclic compounds occupy an important position in the research of organic chemistry. A compound: 591-54-8, is researched, SMILESS is C1=CN=CN=C1N, Molecular C4H5N3Journal, Article, Research Support, Non-U.S. Gov’t, Organic Letters called Cu/N,N’-Dibenzyloxalamide-Catalyzed N-Arylation of Heteroanilines, Author is Chen, Zhixiang; Ma, Dawei, the main research direction is aryl halide heteroarylamine arylation copper oxalamide; diarylamine preparation; copper oxalamide arylation catalyst.Recommanded Product: 4-Aminopyrimidine.
N,N’-Dibenzyloxalamide (DBO) was identified as a powerful ligand for promoting Cu-catalyzed coupling of heteroanilines with (hetero)aryl halides. For (hetero)aryl chlorides, the coupling reaction occurred at 130 °C with 5 mol % CuBr and 10 mol % DBO. For (hetero)aryl bromides/iodides, coupling reaction took place at 80-100 °C with 1 mol % CuI and 2 mol % DBO. A variety of heteroanilines worked well to afford the arylation products in good to excellent yields.
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