The reaction of an aromatic heterocycle with a proton is called a protonation. One of articles about this theory is 《Optimization of fermentation conditions of microbial enzymatic synthesis of L-cysteine》. Authors are Kou, Guang-hui; Huai, Li-hua; Bai, Gang; Yang, Wen-bo.The article about the compound:2-Amino-4,5-dihydrothiazole-4-carboxylic acidcas:2150-55-2,SMILESS:O=C(C1N=C(N)SC1)O).Formula: C4H6N2O2S. Through the article, more information about this compound (cas:2150-55-2) is conveyed.
Pseudomonas sp. TS1138 was used as the test strain to produce L-cysteine, and microbial enzymic synthesis of L-cysteine was studied. In the medium optimization, it was found that glucose and urea were the best carbon and nitrogen source for enzyme production, resp. Effect of DL-2-amino-Δ2-thiazoline-4-carboxylic acid (DL-ATC) on enzyme production was carried out, and the exptl. result showed that a initial concentration of 5 g/L DL-ATC was found to be optimal for enzyme production Effects of inoculum size, initial pH and liquid volume on enzyme production were investigated. The results indicated that the optimum inoculum size was 10%, and the optimum initial pH was 8.0. The optimum liquid volume was 40 mL culture medium in a 500 mL shaking flask.
Compounds in my other articles are similar to this one(2-Amino-4,5-dihydrothiazole-4-carboxylic acid)Formula: C4H6N2O2S, you can compare them to see their pros and cons in some ways,such as convenient, effective and so on.