Most of the compounds have physiologically active properties, and their biological properties are often attributed to the heteroatoms contained in their molecules, and most of these heteroatoms also appear in cyclic structures. A Journal, Article, ACS Medicinal Chemistry Letters called Scaffold and Parasite Hopping: Discovery of New Protozoal Proliferation Inhibitors, Author is Singh, Baljinder; Bernatchez, Jean A.; McCall, Laura-Isobel; Calvet, Claudia M.; Ackermann, Jasmin; Souza, Julia M.; Thomas, Diane; Silva, Everton M.; Bachovchin, Kelly A.; Klug, Dana M.; Jalani, Hitesh B.; Bag, Seema; Buskes, Melissa J.; Leed, Susan E.; Roncal, Norma E.; Penn, Erica C.; Erath, Jessey; Rodriguez, Ana; Sciotti, Richard J.; Campbell, Robert F.; McKerrow, James; Siqueira-Neto, Jair L.; Ferrins, Lori; Pollastri, Michael P., which mentions a compound: 591-54-8, SMILESS is C1=CN=CN=C1N, Molecular C4H5N3, HPLC of Formula: 591-54-8.
Utilizing a target repurposing and parasite-hopping approach, we tested a previously reported library of compounds that were active against Trypanosoma brucei, plus 31 new compounds, against a variety of protozoan parasites including Trypanosoma cruzi, Leishmania major, Leishmania donovani, and Plasmodium falciparum. This led to the discovery of several compounds with submicromolar activities and improved physicochem. properties that are early leads toward the development of chemotherapeutic agents against kinetoplastid diseases and malaria.
In some applications, this compound(591-54-8)HPLC of Formula: 591-54-8 is unique.If you want to know more details about this compound, you can contact with the author or consult more relevant literature.