Most of the natural products isolated at present are heterocyclic compounds, so heterocyclic compounds occupy an important position in the research of organic chemistry. A compound: 1827-27-6, is researched, SMILESS is NC1=CN=C(C=C1)F, Molecular C5H5FN2Journal, Article, Archiv der Pharmazie (Weinheim, Germany) called Synthesis, cytotoxic characterization, and SAR study of imidazo[1,2-b]pyrazole-7-carboxamides, Author is Demjen, Andras; Alfoeldi, Robert; Angyal, Aniko; Gyuris, Mario; Hackler, Laszlo Jr.; Szebeni, Gabor J.; Woelfling, Janos; Puskas, Laszlo G.; Kanizsai, Ivan, the main research direction is imidazopyrazolecarboxamide preparation antitumor breast leukemia structure activity; Groebke-Blackburn-Bienaymé reaction; anticancer agents; cytotoxic; imidazo[1,2-b]pyrazole; multicomponent reaction.Application of 1827-27-6.
The synthesis and in vitro cytotoxic characteristics of new imidazo[1,2-b]pyrazole-7-carboxamides were investigated. Following a hit-to-lead optimization exploiting 2D and 3D cultures of MCF-7 human breast, 4T1 mammary gland, and HL-60 human promyelocytic leukemia cancer cell lines, a 67-membered library was constructed and the structure-activity relationship (SAR) was determined Seven synthesized analogs exhibited sub-micromolar activities, from which compound 63 (2-(tert-Butyl)-N-(4-fluorophenyl)-3-((2,4,4-trimethylpentan-2-yl)amino)-1H-imidazo[1,2-b]pyrazole-7-carboxamide) exerted the most significant potency with a remarkable HL-60 sensitivity (IC50 = 0.183 μM).
This literature about this compound(1827-27-6)Application of 1827-27-6has given us a lot of inspiration, and I hope that the research on this compound(5-Amino-2-fluoropyridine) can be further advanced. Maybe we can get more compounds in a similar way.