So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic.Tomasik, Piotr researched the compound: 5-Amino-2-fluoropyridine( cas:1827-27-6 ).Related Products of 1827-27-6.They published the article 《3-Phenylazopyridines》 about this compound( cas:1827-27-6 ) in Roczniki Chemii. Keywords: phenyl azo pyridines; azo pyridines phenyl; pyridines azo phenyl; nitrosobenzene amino pyridines; amino pyridines nitrosobenzene; nitro pyridines reduction amines. We’ll tell you more about this compound (cas:1827-27-6).
Hydrogenation of 2-substituted I (X = NO2), under CO2, in MeOH with Pd/C gave I (X = NH2) (II) (method A). II were also prepared by reduction of I (X = NO2) with Fe dust in aqueous AcOH (method B). The II prepared were (R, method of preparation, and % yield given): Me, A, 95; SMe, A, 85; F, B, 70; Cl, B, 73.5; Br, B, 81; iodo, B, 86; MeO, A/B, 90.1/80.5; and AcNH, A/B, 90/70. A mixture of PhNO and II (R = MeO) kept 20 min in 50% aqueous NaOH gave III (R = OMe) (method A). In method B the above reaction was carried out at room temperature in AcOH. Similarly prepared were 7 other III analogs.
In addition to the literature in the link below, there is a lot of literature about this compound(5-Amino-2-fluoropyridine)Related Products of 1827-27-6, illustrating the importance and wide applicability of this compound(1827-27-6).