The preparation of ester heterocycles mostly uses heteroatoms as nucleophilic sites, which are achieved by intramolecular substitution or addition reactions. Compound: 4-Aminopyrimidine( cas:591-54-8 ) is researched.Safety of 4-Aminopyrimidine.Chen, Zhixiang; Ma, Dawei published the article 《Cu/N,N’-Dibenzyloxalamide-Catalyzed N-Arylation of Heteroanilines》 about this compound( cas:591-54-8 ) in Organic Letters. Keywords: aryl halide heteroarylamine arylation copper oxalamide; diarylamine preparation; copper oxalamide arylation catalyst. Let’s learn more about this compound (cas:591-54-8).
N,N’-Dibenzyloxalamide (DBO) was identified as a powerful ligand for promoting Cu-catalyzed coupling of heteroanilines with (hetero)aryl halides. For (hetero)aryl chlorides, the coupling reaction occurred at 130 °C with 5 mol % CuBr and 10 mol % DBO. For (hetero)aryl bromides/iodides, coupling reaction took place at 80-100 °C with 1 mol % CuI and 2 mol % DBO. A variety of heteroanilines worked well to afford the arylation products in good to excellent yields.
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