Application of 118994-89-1. Aromatic heterocyclic compounds can also be classified according to the number of heteroatoms contained in the heterocycle: single heteroatom, two heteroatoms, three heteroatoms and four heteroatoms. Compound: Ethyl oxazole-5-carboxylate, is researched, Molecular C6H7NO3, CAS is 118994-89-1, about Asymmetric Alkyl and Aryl/Azolation of Alkenes via a Single Cu(I) Complex. Author is Ma, Xiaodong; Zhang, Guozhu.
The copper-catalyzed, highly enantioselective alkyl and aryl/azolation of alkenes was reported. The employment of the chiral carbazole-based bisoxazoline (Cbzbox) ligand was critical to the success of this chem. Anionic tridentate ligands improved the reducibility of copper complexes, facilitating alkyl/aryl radical generation and provided good enantiocontrol in the azolation. The three-component coupling reactions featured mild reaction conditions and tolerate broad range of functional groups. This strategy allowed straightforward introduction of valuable azole functionalities into a elaborated mol. system through direct C-H functionalization.
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