Synthetic Route of 89123-58-0, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 89123-58-0, name is 5-Bromopyrazine-2,3-diamine belongs to Pyrazines compound, it is a common compound, a new synthetic route is introduced below.
(b)Add Compound II (7.8 g, 41.3 mmol, 1 eq) to a 250 mL vial and add 80 mL of DMF (ie N,N-dimethylformamide) under constant stirring to dissolve Compound II and add the original Triethyl formate (7.34 g, 49.5 mmol, 1.2 eq) and 20 ml formic acid (about 1 drop/sec)Heating under reflux for 24 h under nitrogen protection(At this time, the TLC test is basically free of raw materials); the solvent is spun off, and methanol is dissolved.Purification by silica gel column chromatography gave 5 g of compound III.
The synthetic route of 5-Bromopyrazine-2,3-diamine has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Suzhou Derivative Biological Technology Co., Ltd.; Liu Ke; (7 pag.)CN108707150; (2018); A;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem