Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 109-08-0, name is 2-Methylpyrazine, A new synthetic method of this compound is introduced below., SDS of cas: 109-08-0
Example 10 Synthesis of (1-CYANOCYCLOPROPYL)-3-PYRAZIN-2-YLMETHANESULFONYL-2 (R)- (2, 2, 2-TRIFLUORO-1 (S)- 4-fluorophenylethylamino) propionamide AND N-(1-CYANOCYCLOPROPYL)-3-PYRAZIN-2-YLMETHANE- SULFONYL-2 (R)- (2, 2, 2-TRIFLUORO-L (R)-4-FLUOROPHENYLETHYLAMINO) propionamide STEP 1 A mixture of 2-methylpyrazine (7.0 g, 74.4 mmol), N-CHLOROSUCCINAMIDE (12.6 g, 94.4 MMOL), and benzoyl peroxide (0.1 g, 0.41 mmol) in carbon tetrachloride (200 mL) was heated to reflux for 16 h. The resulting dark heterogeneous solution was filtered, the filtrate concentrated, and the residue purified by flash chromatography (EtOAC/hexanes) to give 2-chloromethyl- pyrazine.
The synthetic route of 109-08-0 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; AXYS PHARMACEUTICALS, INC.; WO2005/28429; (2005); A2;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem