Safety of 2-Amino-4,5-dihydrothiazole-4-carboxylic acid. The fused heterocycle is formed by combining a benzene ring with a single heterocycle, or two or more single heterocycles. Compound: 2-Amino-4,5-dihydrothiazole-4-carboxylic acid, is researched, Molecular C4H6N2O2S, CAS is 2150-55-2, about Development of magnetic carbon nanotubes for dispersive micro solid phase extraction of the cyanide metabolite, 2-aminothiazoline-4-carboxylic acid, in biological samples. Author is Li, Sun Yi; Petrikovics, Ilona; Yu, Jorn.
2-Aminothiazoline-4-carboxylic acid (ATCA) is a minor metabolite of cyanide and is suggested to be a promising biomarker for cyanide exposure due to its specificity to cyanide metabolism and its excellent short- and long-term stability during storage. In this study, magnetic carbon nanotubes, including magnetic multi-walled carbon nanotubes (Mag-MWCNT) and magnetic single-walled carbon nanotubes (Mag-SWCNT) were synthesized as a novel sorbent for dispersive micro solid phase extraction (d-μSPE) to extract ATCA from biol. matrixes. ATCA spiked deionized water samples with the addition of the isotopic internal standard (ATCA – 13C, 15N) were subjected to Mag-CNT/d-μSPE to confirm extraction efficiency of this new technique. The extracted ATCA was derivatized and quantitated using gas chromatog./mass spectrometry (GC/MS) anal. The extraction parameters were optimized and a detection limits of 15 and 25 ng/mL were obtained for synthetic urine and bovine blood resp. with a linear dynamic range of 30-1000 ng/mL. The optimized Mag-CNT/d-μSPE method facilitated efficient extraction of ATCA using 2 mg of Mag-MWCNT with a 10-min extraction time. The current assay was also found to be effective for the extraction of ATCA with average recoveries of 97.7% and 96.5% from synthetic urine and bovine blood resp. The approach of using Mag-CNT to facilitate d-μSPE offered a novel alternative to extract ATCA from complex biol. matrixes.
There is still a lot of research devoted to this compound(SMILES：O=C(C1N=C(N)SC1)O)Safety of 2-Amino-4,5-dihydrothiazole-4-carboxylic acid, and with the development of science, more effects of this compound(2150-55-2) can be discovered.