So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic.Mukherjee, Paramita; Woroch, Cristian P.; Cleary, Leah; Rusznak, Mark; Franzese, Ryan W.; Reese, Matthew R.; Tucker, Joseph W.; Humphrey, John M.; Etuk, Sarah M.; Kwan, Sabrina C.; am Ende, Christopher W.; Ball, Nicholas D. researched the compound: 5-Amino-2-fluoropyridine( cas:1827-27-6 ).Electric Literature of C5H5FN2.They published the article 《Sulfonamide Synthesis via Calcium Triflimide Activation of Sulfonyl Fluorides》 about this compound( cas:1827-27-6 ) in Organic Letters. Keywords: calcium triflimide sulfonyl fluoride amine nucleophilic addition; sulfonamide synthesis. We’ll tell you more about this compound (cas:1827-27-6).
A method using calcium triflimide [Ca(NTf2)2] as a Lewis acid to activate sulfonyl fluorides toward nucleophilic addition with amines is described. The reaction converts a wide array of sterically and electronically diverse sulfonyl fluorides and amines into the corresponding sulfonamides in good yield.
There is still a lot of research devoted to this compound(SMILES：NC1=CN=C(C=C1)F)Electric Literature of C5H5FN2, and with the development of science, more effects of this compound(1827-27-6) can be discovered.