Reference of 109-08-0, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 109-08-0, name is 2-Methylpyrazine belongs to Pyrazines compound, it is a common compound, a new synthetic route is introduced below.
In the glove box,Mn(CO)5Br (0.005mmol), [(E)-2-(2-(1-(2-pyridine)ethylidene))Pyridine] (0.006 mmol), added to 1.0 mL of toluene,After stirring for two hours, 2-methylpyrazine 1a (2 mmol) was added.Benzyl alcohol 2d (1mmol), after reacting at 135 ¡ã C for 48 hours, the reaction was stopped, and the solvent was evaporated to dryness.Column chromatography ethyl acetate / petroleum ether (1:10),Trans-disubstituted olefin derivative 3d. The product was a white solid with a yield of 68percent.
The synthetic route of 2-Methylpyrazine has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Qingdao University of Science and Technology; Zhang Chunyan; (19 pag.)CN108250153; (2018); A;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem