Research on new synthetic routes about 91912-53-7

If you want to learn more about this compound(3-(Pyridin-4-yl)-1H-pyrazol-5-amine)Quality Control of 3-(Pyridin-4-yl)-1H-pyrazol-5-amine, you may wish to communicate with the author of the article,or consult the relevant literature related to this compound(91912-53-7).

In general, if the atoms that make up the ring contain heteroatoms, such rings become heterocycles, and organic compounds containing heterocycles are called heterocyclic compounds. An article called Synthesis and study of the anti-inflammatory properties of some pyrazolo[1,5-a]pyrimidine derivatives, published in 1993-05-31, which mentions a compound: 91912-53-7, Name is 3-(Pyridin-4-yl)-1H-pyrazol-5-amine, Molecular C8H8N4, Quality Control of 3-(Pyridin-4-yl)-1H-pyrazol-5-amine.

A series of pyrazolo[1,5-a]pyrimidin-7-ones I (R = bromophenyl, methoxyphenyl, thienyl, pyridyl, cyclohexyl, Bu, iso-Pr, nitrophenyl, aminophenyl hydrochloride, and ethylpyridinium iodide) were synthesized to evaluate in vivo and in vitro effects induced by structural modifications at the 2 position of 4,7-dihydro-4-ethyl-2-phenylpyrazolo[1,5-a]pyrimidin-7-one (FPP028). This substance, which has been previously studied, is a weak inhibitor of prostaglandin biosynthesis and a nonacid analgesic and anti-inflammatory agent devoid of ulcerogenic properties. To gain more insight into the mechanism of action of this class of compounds, several in vivo tests were carried out, such as carrageenan-induced rat paw edema and pleurisy. In vitro tests include some studies of leukocyte functions, such as superoxide production and myeloperoxidase release. In vitro effects on arachidonic acid-, ADP, and platelet-activating factor-induced platelet aggregation were also studied. Different anti-inflammatory activities were observed, depending on the nature of substituents at the 2 position; these differences are probably linked to the capacity of these compounds to inhibit leukotrienes and/or prostaglandin biosynthesis with different selectivity. 4,7-Dihydro-4-ethyl-2(2-thienyl)pyrazolo[1,5-a]pyrimidin-7-one proved to be the most interesting compound of the novel synthesized series, showing powerful pharmacol. activity in vivo as well as in vitro, together with very weak acute toxicity.

If you want to learn more about this compound(3-(Pyridin-4-yl)-1H-pyrazol-5-amine)Quality Control of 3-(Pyridin-4-yl)-1H-pyrazol-5-amine, you may wish to communicate with the author of the article,or consult the relevant literature related to this compound(91912-53-7).

Reference:
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem