Reference of 59489-39-3,Some common heterocyclic compound, 59489-39-3, name is 2-Amino-6-cyanopyrazine, molecular formula is C5H4N4, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
Intermediate 5 (500 mg, 1.13 mmol) , 6-aminopyrazine-2-carbonitrile (163 mg, 1.36 mmol) , palladium (II) acetate (84 mg, 0.374 mmol) , xantphos (215 mg, 0.374 mmol) and cesium carbonate (741 mg, 2.27 mmol) in 1, 4-dioxane (10 mL) under heating at 110 for 1 hour through microwave irradiation under N2 atmosphere. LC-MS: m/z 526.2 (M+H) +.
The synthetic route of 59489-39-3 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; AGIOS PHARMACEUTICALS, INC.; TRAVINS, Jeremy, M.; KONTEATIS, Zenon, D.; SUI, Zhihua; YE, Zhixiong; (199 pag.)WO2018/39972; (2018); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem