Some common heterocyclic compound, 6705-33-5, name is Pyrazin-2-ylmethanol, molecular formula is C5H6N2O, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. COA of Formula: C5H6N2O
Triphenylphosphine(7.80 g, 29.7 mmol) and phthalimide (4.50 g, 30.6 mmol)were added to a solution of crude 2-(hydroxylmethyl)pyrazine(2.80 g, 25.5 mmol) in dry tetrahydrofuran (200 mL).The stirred solution was then cooled in an ice bath beforediisopropyl azodicarboxylate (5.90 g, 30.4 mmol) wasslowly added over 5 min. The solution was stirred for twodays at room temperature and taken to dryness underreduced pressure and the resulting yellow oil was suspendedin ethanol (20 mL) before again being taken todryness under reduced pressure, producing a thick yellowslurry. The slurry was dissolved in hot ethanol (~200 mL)and left to cool and evaporate to ~50 mL overnight atroom temperature. The resulting solid was filtered off togive the desired product as an analytically pure slightlyyellow solid (3.82 g, 75%). Found: C, 65.14; H, 3.89; N, 17.52.Calc. for C13H9N3O2: C, 65.27; H, 3.79; N, 17.56. 1H NMR (300MHz, CDCl3): delta (ppm) 8.66 (s, 1H, H-3), 8.48 (s, 2H, H-2 +H-1), 7.89-7.92 (m, 2H, phth-H), 7.77-7.74 (m, 2H, phth-H),5.06 (s, 2H, CH2).
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 6705-33-5, its application will become more common.
Reference:
Article; Feltham, Humphrey L. C.; Cowan, Matthew G.; Kitchen, Jonathan A.; Jameson, Guy N. L.; Brooker, Sally; Supramolecular Chemistry; vol. 30; 4; (2018); p. 296 – 304;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem