Related Products of 297172-19-1, These common heterocyclic compound, 297172-19-1, name is 5,6,7,8-Tetrahydroimidazo[1,5-a]pyrazine, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
In 0 C lower, to the 5, 6, 7, 8-tetrahydro-imidazo [1, 5-a] pyrazine (50.0 mg, 0 . 40mmol) and Boc-(R)-3-amino-4-(2, 5-difluorophenyl) butanoic acid (128.0 mg, 0 . 40mmol) in dichloromethane (5 ml) is added in solution HOBT (54.5 mg, 0 . 42mmol). The reaction in the 0 C lower stirring 10 min, then adding EDC (96.6 mg, 0 . 50mmol). After removing the ice bath, the reaction stirring at ambient temperature 14h. The mixture is concentrated and used for purifying HPLC (Gilson; YMC-PackProC18 column, 100x20mmI. D. ; A solvent gradient from 10% acetonitrile, 90% water and 0.1% trifluoroacetic acid to 90% acetonitrile, 10% water and 0.1% trifluoroacetic acid), to obtain 103 mg in the form of a solid as the title compound.
Statistics shows that 5,6,7,8-Tetrahydroimidazo[1,5-a]pyrazine is playing an increasingly important role. we look forward to future research findings about 297172-19-1.
Reference:
Patent; CGene Tech (Suzhou,China)Co.,Ltd; YU, QIANG; WEI, FENGPING; (31 pag.)CN101899047; (2016); B;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem