An article SAR Studies Leading to the Identification of a Novel Series of Metallo-beta-lactamase Inhibitors for the Treatment of Carbapenem-Resistant Enterobacteriaceae Infections That Display Efficacy in an Animal Infection Model WOS:000456349300014 published article about PSEUDOMONAS-AERUGINOSA; ACID in [Leiris, Simon; Coelho, Alicia; Castandet, Jerome; Bayet, Maelle; Lozano, Clarisse; Bougnon, Juliette; Bousquet, Justine; Everett, Martin; Lemonnier, Marc; Sprynski, Nicolas; Zalacain, Magdalena; Davies, David T.] Antabio SAS, 436 Rue Pierre & Marie Curie, F-31670 Labege, France; [Zalacain, Magdalena] Zala Drug Discovery Consulting LLC, W Chester, PA 19380 USA; [Pallin, Thomas David; Cramp, Michael C.; Jennings, Neil; Raphy, Gilles; Jones, Mark W.] 8 9 Spire Green Ctr, Charles River Labs, Harlow CM19 5TR, Essex, England; [Pattipati, Ramesh; Shankar, Battu; Sivasubrahmanyam, Relangi; Soodhagani, Ashok K.; Juventhala, Ramakrishna R.; Pottabathini, Narender; Pothukanuri, Srinivasu] GVK Biosci Private Ltd, Plot 28 A,IDA Nacharam, Hyderabad 500076, India; [Benvenuti, Manuela; Pozzi, Cecilia; Mangani, Stefano] Univ Siena, Dept Biotechnol Chem & Pharm, 2 Via Aldo Moro, I-53100 Siena, Italy; [De Luca, Filomena; Cerboni, Giulia; Docquier, Jean-Denis] Univ Siena, Dept Med Biotechnol, 16 Viale Bracci, I-53100 Siena, Italy; [Pottabathini, Narender] Laurus Labs Ltd, Plot DS1,IKP Knowledge Pk, Hyderabad 500078, Telangana, India in 2019, Cited 24. Computed Properties of C5H4N2O2. The Name is Pyrazine-2-carboxylic acid. Through research, I have a further understanding and discovery of 98-97-5
The clinical effectiveness of carbapenem antibiotics such as meropenem is becoming increasingly compromised by the spread of both metallo-beta-lactamase (MBL) and serine-beta-lactamase (SBL) enzymes on mobile genetic elements, stimulating research to find new beta-lactamase inhibitors to be used in conjunction with carbapenems and other beta-lactam antibiotics. Herein, we describe our initial exploration of a novel chemical series of metallo-beta-lactamase inhibitors, from concept to efficacy, in a survival model using an advanced tool compound (ANT431) in conjunction with meropenem.
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Reference:
Patent; Chevron Research Company; US4732894; (1988); A;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem