Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 32974-92-8, name is 1-(3-Ethylpyrazin-2-yl)ethanone, A new synthetic method of this compound is introduced below., Computed Properties of C8H10N2O
General procedure: The ligands L1-L4 were synthesized by reflux method. Shown in Scheme 1, 5mM of 2-Acetyl-3-ethylpyrazine and thiosemicarbazides (L1), 5mM of 2-Acetyl-3-ethylpyrazine and 4-methylthiosemicarbazide (L2), 5mM of 2-Acetyl-3-ethylpyrazine and 4-phenylthiosemicarbazide (L3), and 5mM of 2-Acetyl-3-ethylpyrazine and 3-pyrrolethiosemicarbazide (L4) were stirred in CH3OH for 3 h at 65C. The ligands were precipitated and filtered. L1-L4 were characterized by infrared spectroscopy, electrospray ionization mass spectrometry (ESI-MS), 1H NMR, and 13C NMR (Supplementary Figs S4- S31). L1: 2-Acetyl-3-ethylpyrazine-thiosemicarbazides; yield:79.6%. Anal. Calcd (%) for C9H13N5S: C, 48.41; H, 5.87; N, 31.36; S, 16.36. Found: C, 48.32; H, 5.80; N, 31.43; S, 16.40. IR, cm-1: 3430.8 (s, amide), 3234.7 (s, NH), 3158.7 (m, aromatic hydrogen), 1598.16, 1504.69, 1459 (s, aromatic), 1396.96 (m, C=N), 1293.39 (s, thioamide), 1155, 1102.57, 880 (m, C-H), 715 (m, C=S), 596. m/z (ESI): calcd for C9H13N5S, 222.08 [M-H]-. 1H NMR (400MHz, DMSO) delta 10.48 (s, 1H), 8.55 (d, J=2.4Hz, 1H), 8.49 (d, J=2.4Hz, 1H), 8.38 (s, 1H), 7.60 (s, 1H), 3.04 (q, J=7.4Hz, 2H), 2.35 (s, 3H), 1.20 (t, J=7.4Hz, 3H); 13C NMR (100MHz, DMSO) delta 179.42, 156.21, 150.18, 148.02, 142.99, 140.68, 28.00, 15.87, 12.75.
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.
Reference:
Article; Khan, Muhammad Hamid; Cai, Meiling; Li, Shanhe; Zhang, Zhenlei; Zhang, Juzheng; Wen, Xiaoan; Sun, Hongbin; Liang, Hong; Yang, Feng; European Journal of Medicinal Chemistry; vol. 182; (2019);,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem