Application of 63286-28-2

At the same time, in my other blogs, there are other synthetic methods of this type of compound, 2-Chloro-3-hydrazinylpyrazine, and friends who are interested can also refer to it.

Adding a certain compound to certain chemical reactions, such as: 63286-28-2, name is 2-Chloro-3-hydrazinylpyrazine, belongs to Pyrazines compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 63286-28-2, Recommanded Product: 2-Chloro-3-hydrazinylpyrazine

[00118] To a 0 0C solution of l-(4-chlorophenyl)cyclobutanecarboxylic acid (105.3 mg, 0.50 mmol) in THF (2 mL) was added 4-methylmorpholine (60.5 muL, 0.55 mmol). The reaction mixture was stirred for 10 minutes, and then isobutyl chloroformate (67.4 muL, 0.52 mmol) was added dropwise over a 2 minute period. Upon completion of addition, the reaction mixture was stirred for 1 h. A solution of Compound IA (72.3 mg, 0.50 mmol) in THF (3 mL) was then added dropwise over a 2 minute period. The resulting mixture was stirred for 10 minutes and then the cooling bath was removed. The reaction mixture was allowed to warm to room temperature where it stirred for 1 h. After this time, water (5 mL) and ethyl acetate (10 mL) were added, and the resulting mixture was stirred for 10 minutes. At the conclusion of this period, the organic phase was separated, dried over Na2SO4, and then concentrated in vacuo. The resulting residue was purified by flash chromatography (SiO2, 0-60% ethyl acetate / hexanes) to afford compound 2A, which was used directly in the preparation of compound 2B set forth below. LC/MS (m/z) = 337 (M+H)+.

At the same time, in my other blogs, there are other synthetic methods of this type of compound, 2-Chloro-3-hydrazinylpyrazine, and friends who are interested can also refer to it.

Reference:
Patent; BRISTOL-MYERS SQUIBB COMPANY; WO2008/130951; (2008); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem