In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 41110-33-2, name is Methyl 5-methylpyrazine-2-carboxylate belongs to Pyrazines compound, it is a common compound, a new synthetic route is introduced below. Product Details of 41110-33-2
A solution of LAH (164.0 mL, 0.164 mol, 1.0 M in THF, 0.5 equiv.) was added to a suspension of methyl 5-methylpyrazine-2-carboxylate (50 g, 0.328 mol, 1.0 equiv.) in anhydrous THF (750 mL) at -78C. The internal temperature was kept below -72 C during the addition of LAH. On completion of addition, the reaction mixture was left, to stir at -78 C for a further 20 mm and then quenched with glacial AcOH (50.0 mL) at the same temperature. The resulting mixture was warmed to RT and the volatiles were removed by evaporation under pressure. The residue was dissolved in hydrochloric acid (1.5N, 500 mL) and extracted with DCM (2 x 2 L). The extracts were combined, washed with a saturated aqueous sodium hydrogen carbonate solution (2 x 500 mL), (Note: no product was observed in the HC1 or aqueous sodium hydrogen carbonate solution) dried over anhydrous Na2SO4, and concentrated in vacuo to yield a brown oil. The initial product was purified by column chromatography (silica gel 60-120 mesh) eluting with a gradient of 10% EtOAc in petroleum ether to provide the title compound as a pale yellow liquid (21.3 g, 53 %). TLC Info: (9.0/1.0 petroleum ether/EtOAc). 1H NMR (400 MHz, CDC13)o 10.14 (s, 1H), 9.07 (d,J= 1.5 Hz, 1H), 8.63 (d,J= 1.4 Hz, 1H), and 2.70 (s, 3H). LCMS-ESI (pos.) m/z:123 (M+H)t
The synthetic route of 41110-33-2 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; AMGEN INC.; CHEN, Yinhong; DRANSFIELD, Paul John; HARVEY, James S.; HEATH, Julie Anne; HOUZE, Jonathan; KHAKOO, Aarif Yusuf; KOPECKY, David J.; LAI, Su-Jen; MA, Zhihua; NISHIMURA, Nobuko; PATTAROPONG, Vatee; SWAMINATH, Gayathri; YEH, Wen-Chen; RAMSDEN, Philip Dean; (434 pag.)WO2018/93577; (2018); A1;,
Pyrazine – Wikipedia,
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