Electric Literature of 54608-52-5,Some common heterocyclic compound, 54608-52-5, name is 2-Hydrazinopyrazine, molecular formula is C4H6N4, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
[0641] to a solution of compound methyl 2,4-dioxopentanoate (100 mg, 693.82 umol) in AcOH (20 ml) was added compound 63a (76.4 mg, 693.82 umol). The mixture was stirred at 120 C for 1 hour. The mixture was in DCM (5 ml). The organic layer was washed with water (10 ml), NaHCO3 to ph ~ 8-9 and dried over Na2SO4 and concentrated to afford compound 63b (500 mg, 25.24% yield) as white solid.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 2-Hydrazinopyrazine, its application will become more common.
Reference:
Patent; BLADE THERAPEUTICS, INC.; BUCKMAN, Brad, Owen; YUAN, Shendong; ADLER, Marc; EMAYAN, Kumaraswamy; MA, Jingyuang; (687 pag.)WO2018/64119; (2018); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem