Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 36070-80-1, name is 5-Chloropyrazine-2-carboxylic acid, A new synthetic method of this compound is introduced below., Recommanded Product: 36070-80-1
Step E: 5-Chloro-pyrazine-2-carbonyl chloride. A suspension of 5-chloro-pyrazine-2-carboxylic acid (2.49 g, 15.7 mmol) in thionyl chloride (15 mL) was heated to reflux for 1 h. The solid slowly dissolved. The bulk of the thionyl chloride was removed in vacuo, and the final traces of thionyl chloride were removed in vacuo as an azeotrope with toluene by addition of toluene and subsequent concentration repeated three times. The acid chloride was thus obtained as a reactive, yellow semi-solid. 1H NMR (400 MHz, CDCl3): delta 9.09 (d, J=1.3 Hz, 1H), 8.77 (d, J=1.3 Hz, 1H).
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.
Reference:
Patent; Allison, Brett D.; Grice, Cheryl A.; Letavic, Michael A.; US2009/131416; (2009); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem