Reference of 313339-92-3, A common heterocyclic compound, 313339-92-3, name is 3,5-Dichloropyrazine-2-carbonitrile, molecular formula is C5HCl2N3, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
3,5-Dichloropyrazine-2-carbonitrile (Example 12, Step 2, 31.0 g, 178.18 mmol) was dissolved in anhydrous diethyl ether (890 mL, 0.2M) and cooled to -78 C. Then MeMgBr in diethyl ether (3.0 M, 65.33 mL, 190.0 mmol) was added slowly to maintain low temperature. After the addition was complete, the mixture was slowly warmed room temperature and stirred 1 h. The mixture was poured into a beaker containing a mixture of HCl in water (1.0 M, 1 L) and ice (1 kg). The mixture was stirred vigorously for 10 min. The mixture was extracted with diethyl ether (3*1 L), the combined organic layers were dried over sodium sulfate and concentrated under reduced pressure to afford the title compound as an orange oil (34 g, 99% yield). The mixture was used for the next reaction without further purification.
The synthetic route of 313339-92-3 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; FLX Bio, Inc.; Beck, Hilary Plake; Biannic, Berenger; Bui, Minna Hue Thanh; Hu, Dennis X.; Jackson, Jeffrey J.; Ketcham, John Michael; Powers, Jay Patrick; Reilly, Maureen Kay; Robles-Resendiz, Omar; Shunatona, Hunter Paul; Walker, James Ross; Wustrow, David Juergen; Younai, Ashkaan; Zibinsky, Mikhail; (339 pag.)US2018/72743; (2018); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem