Some common heterocyclic compound, 56423-63-3, name is 2-Bromopyrazine, molecular formula is C4H3BrN2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. COA of Formula: C4H3BrN2
Dissolve YC042 (100 mg, 0.4 mmol) and 2-bromopyrazine (127 mg, 0.8 mmol) in DME.Add 1.6 mL of 2M sodium carbonate aqueous solution, and then introduce nitrogen after evacuation. Add catalyst Pd (dppf) 2Cl2-CH2Cl2 (17mg). After evacuation again, introduce nitrogen, reflux at 95 C overnight, dilute with water, extract with ethyl acetate, organic The phases were dried over anhydrous sodium sulfate and spin-dried and purified on a normal phase silica gel column.YC075 (75.8mg)
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 56423-63-3, its application will become more common.
Reference:
Patent; Chinese Academy Of Sciences Shanghai Pharmaceutical Institute; Zhao Yujun; Li Jia; Wang Zengtao; Zhang Shiyan; Zang Yi; Wang Peipei; Sun Dandan; Zhang Hanyan; (155 pag.)CN110818683; (2020); A;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem