Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 36070-80-1, name is 5-Chloropyrazine-2-carboxylic acid, A new synthetic method of this compound is introduced below., Safety of 5-Chloropyrazine-2-carboxylic acid
To a solution of 5-chloropyrazine-2-carboxylic acid (2 g) in dichloromethane (20 mL) were added DMF (0.05 mL) and oxalyl chloride (1.3 mL), followed by stirring at room temperature for 1 hour. The reaction mixture was concentrated under reduced pressure and azeotroped with toluene. To the residue was added dichloromethane (20 mL), followed by ice-cooling, and triethylamine (4 mL) and ethyl (2E)-amino(hydroxy)iminoacetate (2 g) were added thereto, followed by stirring at the same temperature for 15 minutes. To the reaction mixture was added a saturated aqueous sodium hydrogen carbonate solution, followed by extraction with chloroform. The solid remaining in the aqueous layer was collected by filtration and dried under reduced pressure to obtain ethyl (2E)-amino({[(5-chloropyrazin-2-yl)carbonyl]oxy}imino)acetate (1.4 g) as a colorless solid. Further, the organic layer was washed with a saturated aqueous sodium chloride solution, dried over anhydrous magnesium sulfate, and then concentrated under reduced pressure to obtain ethyl (2E)-amino({[(5-chloropyrazin-2-yl)carbonyl]oxy}imino)acetate (1.9 g) as a yellow solid.
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.
Reference:
Patent; Astellas Pharma Inc.; EP2511265; (2012); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem