In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 23611-75-8 as follows. Formula: C6H5ClN2O2
A suspension of methyl 6-chloropyrazine-2-carboxylate (3.4 g, 19.7 mmol) in THF (100 mL) was cooled to below 10 C and treated dropwise with 3M MeMgBr (Et20, 13.13 mL, 39.4 mmol), maintaining the reaction temperature below 10 C. The reaction mixture was then allowed to warm to RT. After 1 hr, the reaction mixture was concentrated then taken up in 1M HCI (aq, 150 mL) and extracted with EtOAc (3 x 70 mL). The organic layers were combined, dried (Mg504), filteredand concentrated on to silica (4 g). The crude product was purified by chromatography on silica gel (40 g column, 20-70% EtOAc/iso-hexane) to afford 2-(6-chloropyrazin-2-yl)propan-2-ol (1 .4 g, 7.71 mmol, 39% yield) as an orange oil; Rt 1.30 mins (HPLC acidic); mlz 173 (M+H) (ES); 1H NMR (500 MHz, DMSO-d6) 6 8.87 (d, J = 0.5 Hz, 1 H), 8.67 (d, J = 0.5 Hz, 1 H), 5.61 (s, 1 H), 1.46 (s, 6H).
According to the analysis of related databases, 23611-75-8, the application of this compound in the production field has become more and more popular.
Reference:
Patent; STEP PHARMA S.A.S.; QUDDUS, Abdul; NOVAK, Andrew; COUSIN, David; CHATZOPOULOU, Elli; BLACKHAM, Emma; JONES, Geraint; THOMAS, Jennifer; WRIGGLESWORTH, Joseph; DUFFY, Lorna; BIRCH, Louise; GEORGE, Pascal; AHMED, Saleh; (277 pag.)WO2019/106156; (2019); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem