In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 55557-52-3, name is 3-Chloropyrazine-2-carbonitrile belongs to Pyrazines compound, it is a common compound, a new synthetic route is introduced below. COA of Formula: C5H2ClN3
Step 1: [6-(3-Cyano-pyrazin-2-yloxy)-l-hydroxy-4-methyl-l,3-dihydro- benzo[c] [ 1 ,2] oxaborol-3-yl] -acetic acid ethyl ester I *- CCfeEt[0598] To a solution of ethyl 2-(l ,6-dihydroxy-4-methyl- 1 ,3-dihydrobenzo[c] [ 1 ,2] oxaborol-3-yl)acetate (1.0 g, 4.0 mmol) and S-chloro-pyrazine^-carbonitrile (0.84 g, 6.0 mmol) in DMF (24 mL) was added cesium carbonate (2.68 g, 8.8 mmol). The mixture was heated to 8O0C for 2 hrs. The reaction was cooled down, diluted withH2O, acidified to pH 3 with aqueous HCl (IN). The mixture was extracted with ethyl acetate. The organic phase was separated, dried (Na2SO4), and concentrated. The residue was purified by column chromatography (silica, Hexanes/Ethyl acetate = 1 : 4) affording the title compound (1.30 g, 92%) as a white solid. 1H NMR (CDCl3) delta 8.40 (d, IH), 8.29 (d, IH), 7.36 (d, IH), 7.11 (d, IH), 5.69 (dd, IH), 4.81 (s, IH), 4.20 (q, 2H), 3.11 (dd, IH), 2.44 (dd, IH), 2.39 (s, 3H), 1.26 (t, 3H). MS found: (M+H)+ = 354.
The synthetic route of 55557-52-3 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; ANACOR PHARMACEUTICALS, INC.; GLAXOSMITHKINE LLC; XIA, Yi; ALLEY, Michael, Richard Kevin; ZHOU, Yasheen; SINGH, Rajeshwar; DING, Charles; CAO, Kathy; PLATTNER, Jacob, J.; OU, Ligong; JIA, Guofeng; SARASWAT, Neerja; RAMACHANDRAN, Sreekanth; ZHOU, Ding; WO2011/17125; (2011); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem