1053656-22-6, name is 7-tert-Butyl 2-ethyl 5,6-dihydroimidazo[1,2-a]pyrazine-2,7(8H)-dicarboxylate, belongs to Pyrazines compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. HPLC of Formula: C14H21N3O4
0081] Method A-Step c: Preparation of tert-butyl 2-(hydroxymethyl)-5,6- dihydroi [0082] To a stirred solution of 7-tert-butyl 2-ethyl 5,6-dihydroimidazo[l,2-a]pyrazine – 2,7(8H)-dicarboxylate (50 mg, 0.17 mmol) in anhydrous THF (2 mL) was added L1AIH4 (13 mg, 0.34 mmol) batches at 0 C. The mixture was stirred at the same temperature for 30 minutes. TLC showed that the reaction was complete. The reaction mixture was quenched with Na2S04.10H2O. The mixture was dried over anhydrous Na2S04> filtered and concentrated in vacuo. The residue was purified by silica gel column chromatography (CH2Cl2:MeOH = 50: 1) to give a colorless oil (30 mg, 69.8%). *H NMR (400 MHz, CDC13) delta 6.81 (s, 1H), 4.67 (s, 2H), 4.57 (s, 2H), 3.95 (d, / = 5.2 Hz, 2H), 3.84 (s, 2H), 1.48 (s, 9H).
The synthetic route of 1053656-22-6 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; ZHANG, Xiaohu; WO2014/113191; (2014); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem