1057216-55-3, name is 2-Chloro-5-iodopyrazine, belongs to pyrazines compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. SDS of cas: 1057216-55-3
Intermediate 31 (350 mg, 1.05 mmol), 2-chloro-5-iodopyrazine (252 mg, 1.05 mmol), 2M aqueous sodium carbonate solution (1.58 mL, 3.16 mmol) and anhydrous DMSO (5 mL) were charged to a sealed tube. The mixture was degassed by bubbling with nitrogen for 5 minutes before the addition of tetrakis(triphenylphosphine)20 palladium(0) (61 mg, 0.05 mmol). The reaction mixture was sealed under nitrogen andstirred at 110C for 1 h. The mixture was diluted with water (40 mL) and extracted with EtOAc (3 x 20 mL). The organic phase was washed with saturated aqueous sodium bicarbonate solution (2 x 10 mL) followed by brine (10 mL), then dried over sodium sulfate and concentrated under vacuum. The residue was purified by FCC, eluting with17-80% EtOAc in heptane, to afford the title compound (285 mg, 54% at 80% purity) as an off white solid. oH (500 MHz, CDC13) 8.73-8.64 (m, 2H), 8.63-8.59 (m, 1H), 7.92 (s, 2H), 7.33-7.27 (m, 1H), 7.17 (d, J8.2 Hz, 1H), 7.15-7.07 (m, 1H), 7.00 (d, J6.6 Hz, 1H),6.67 (t, J73.5 Hz, 1H), 4.36 (s, 2H), 2.60 (s, 3H). Method C HPLC-MS: MH+ m/z 401,
The synthetic route of 1057216-55-3 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; UCB PHARMA S.A.; BENTLEY, Jonathan Mark; BROOKINGS, Daniel Christopher; BROWN, Julien Alistair; CAIN, Thomas Paul; CHOVATIA, Praful Tulshi; FOLEY, Anne Marie; GALLIMORE, Ellen Olivia; GLEAVE, Laura Jane; HEIFETZ, Alexander; HORSLEY, Helen Tracey; HUTCHINGS, Martin Clive; JACKSON, Victoria Elizabeth; JOHNSON, James Andrew; JOHNSTONE, Craig; KROEPLIEN, Boris; LECOMTE, Fabien Claude; LEIGH, Deborah; LOWE, Martin Alexander; MADDEN, James; PORTER, John Robert; QUINCEY, Joanna Rachel; REED, Laura Claire; REUBERSON, James Thomas; RICHARDSON, Anthony John; RICHARDSON, Sarah Emily; SELBY, Matthew Duncan; SHAW, Michael Alan; ZHU, Zhaoning; WO2014/9295; (2014); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem