Related Products of 153800-11-4, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 153800-11-4 name is 2-Ethynylpyrazine, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
To a stirred solution of alkyne precursor 8b-16b (1.2 equiv) in THF was added dropwise a 1.0 M solution of TBAF in THF (1.44 equiv). The reaction mixture was stirred at room temperature for about 15 min. TLC analysis showed complete conversion of starting material to a major product (the de-silylation intermediate was slightly more polar than the alkyne precursor). The glycosyl azide (1.0 equiv), and 1:1 tert-butyl alcohol-water were then added to the above solution. A solution of sodium ascorbate (0.4 equiv) in water, followed by CuSO4 (0.2 equiv) in water, was successively added. The bright-yellow suspension was stirred vigorously at room temperature overnight. TLC analysis showed complete conversion of the starting material to a major product. The mixture was evaporated under reduced pressure, and the resultant residue was purified by flash chromatography to yield pure material.
At the same time, in my other blogs, there are other synthetic methods of this type of compound, 2-Ethynylpyrazine, and friends who are interested can also refer to it.
Reference:
Article; Li, Tiehai; Guo, Lina; Zhang, Yan; Wang, Jiajia; Li, Zhonghua; Lin, Lin; Zhang, Zhenxing; Li, Lei; Lin, Jianping; Zhao, Wei; Li, Jing; Wang, Peng George; Carbohydrate Research; vol. 346; 9; (2011); p. 1083 – 1092;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem