Synthetic Route of 59489-71-3, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 59489-71-3, name is 2-Amino-5-bromopyrazine, This compound has unique chemical properties. The synthetic route is as follows.
To the solution of a 5-bromo-pyrazine-2-amine according to formula (ii) (10 g, 57.47 mmol) in 1,4-dioxane (100 ml) was added 4-methoxycarbonylphenylboronic acid (11.377 g, 63.21 mmol) followed by potassium phosphate tribasic (14.638 g, 68.96 mmol) and water 68.96 ml at RT. Reaction mixture was purged with N2 gas for lh. Bis(triphenylphosphine)palladium(II)chloride (2.823 g, 4.02 mmol) was added to the reaction mixture. The reaction mixture was heated to reflux for 16h, cooled to RT and concentrated under vacuum to remove dioxane. Solid was filtered, washed with water ( 20 ml X 3), dried and again washed with MeOH (10 ml X 4) and dried to afford compound a methyl carboxylate intermediate of formula (xiv) (12.035 g, 91.36%, 84% purity) as pale yellow solid.
The chemical industry reduces the impact on the environment during synthesis 2-Amino-5-bromopyrazine. I believe this compound will play a more active role in future production and life.
Reference:
Patent; UNIVERSITY OF CAPE TOWN; MMV MEDICINES FOR MALARIA VENTURE; YOUNIS, Yassir; CHIBALE, Kelly; WITTY, Michael, John; WATERSON, David; WO2013/121387; (2013); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem