Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 179323-60-5, name is 1-(Pyrazin-2-yl)ethanamine, A new synthetic method of this compound is introduced below., name: 1-(Pyrazin-2-yl)ethanamine
To a mixture of 5-(isobutyl(methyl)carbamoyl)-4′-methylbiphenyl-3-carboxylic acid (21 mg, 0.064 mmol), N-(3-dimethylaminopropyl)-N’-ethylcarbodiimide hydrochloride (25 mg, 0.13 mmol), 1-hydroxybenzotriazole hydrate (9.9 mg, 0.064 mmol), and CH2Cl2 (3 mL) were added l-(pyrazin-2- yl)ethanamine (12 mg, 0.097 mmol) and NN-diisopropylethylamine (17 muL, 0.097 mmol). The mixture was stirred at room temperature overnight, and then concentrated in vacuo. The residue was purified by preparative HPLC (100 x 21.2 mm Cl 8 column, 30-70% MeCnu/water[10 mM Et2NH]) to afford a white foam.LC-MS: 431.1 [M+l]+; 1H NMR (400 MHz, CD3OD): (rotamers) delta 8.70 (s, IH), 8.59 (m, IH), 8.49 (d, IH, J = 2.8 Hz), 8.20 (t, IH, J = 1.6 Hz), 7.84-7.75 (m, 2H), 7.62-7.57 (m, 2H), 7.30 (d, 2H, J = 8.0 Hz), 5.36 (q, IH, J = 7.2 Hz), 3.42 (d, IH, J = 7.6 Hz), 3.19 (d, IH, J = 7.6 Hz), 3.10 and 3.01 (s, 3H), 2.39 (s, 3H), 2.15 and 1.98 (m, IH), 1.66 (d, 3H, J = 7.2 Hz), 1.02 and 0.78 (d, 6H, J = 6.4 Hz).
The synthetic route of 179323-60-5 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; RENOVIS, INC.; WO2009/110985; (2009); A2;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem