Adding a certain compound to certain chemical reactions, such as: 22047-25-2, name is Acetylpyrazine, belongs to pyrazines compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 22047-25-2, Formula: C6H6N2O
In a 250mL round-bottom flask, 2-acetylpyrazine (1.22g, 10.00mmol) was added to a solution of 4-chlorobenzaldehyde (0.700g, 5.00mmol) in EtOH (30mL) upon stirring. KOH pellets (0.560g, 10.0mmol) were then added, and followed by aqueous NH3 (28%, 25mL). The resulting brownish solution was stirred at room temperature overnight, during which time gray solid had formed. The solid was collected by filtration, washed with EtOH and dried in vacuo over P2O5. L2 was isolated as pure product (1.00g, 58.0%). UV-Vis lambdamax/nm (2.5×10-5moldm-3, CH2Cl2-MeOH) 250 (epsilon/103dm3mol-1cm-1 18.7), 285 (26.1), 320sh (8.1). FT-IR (solid, cm-1): 1603s, 1571w, 1521w, 1496s, 1472m, 1428m, 1372s, 1245w, 1117m, 1050m, 1017s, 852m, 822s, 738w, 690m. 1H NMR (400MHz, CDCl3)delta 9.92 (s, 2 H, HA3), 8.85(dd, J=6.4, 1.0Hz, 4 H, HA5/A6), 8.72 (s, 2 H, HB3), 8.03(d, J=8.7Hz, 2H, HC3), 7.67 (d, J=7.67Hz, 2 H, HC2) ppm; 13CNMR (101MHz, CDCl3)delta154.39, 149.58, 148.79, 145.59, 144.10, 143.11, 134.71, 129.44, 128.95, 118.97ppm. HR-MS: m/z 346.0863 [M+H]+ (calc. 346.0859), 368.0679 [M+Na]+ (calc. 368.0679).
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, Acetylpyrazine, other downstream synthetic routes, hurry up and to see.
Reference:
Article; Li, Li; Liu; Xiong, Hangxing; Chan, Corinna; Manke, David R.; Golen, James A.; Zhang, Guoqi; Polyhedron; vol. 132; (2017); p. 64 – 69;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem