Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 14667-55-1, name is 2,3,5-Trimethylpyrazine, A new synthetic method of this compound is introduced below., SDS of cas: 14667-55-1
Take 2,3,5-trimethylpyrazine (16.3 mL, 98.7 mmol) in a 500 mL round bottom flask, glacial acetic acid (60 mL) and 30% hydrogen peroxide (50 mL) were slowly added with a constant pressure funnel while stirring in an ice bath, the reaction solution was stirred and heated in an oil bath at 60 C, an equal amount of 30% hydrogen peroxide was added dropwise to the reaction solution, and the mixture was stirred for 20 hours, cooled to room temperature, water (50 mL) was added, rhoEta was adjusted = 9 with saturated K2C03, extracted with DCM (200mLX4), the organic phase was washed with saturated brine (200 mL), dried over anhydrous sodium sulfate, the organic phase was concentrated to give 12.4 g of a pale yellow oily liquid, yield was 76%.
The synthetic route of 14667-55-1 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Guizhou Medical University; Fan Lingling; Tang Lei; Li Yi; Li Yong; Liu Jian; Chu Liangzhao; (28 pag.)CN108558833; (2018); A;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem