In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 117719-17-2, name is 5-Bromo-3-morpholinopyrazin-2-amine belongs to pyrazines compound, it is a common compound, a new synthetic route is introduced below. name: 5-Bromo-3-morpholinopyrazin-2-amine
5-bromo-3-morpholin-4-yl-pyrazin-2-ylamine (5 g, 1 eq) was suspended in DME (30 mL) and dimethyl 3-bromo-2-oxopentanedioate (7.33 g, 1 .5 eq) was added. The reaction mixture was heated in a sealed tube at 90C for 27 h and then at 70 C for 48 h. On cooling, the reaction mixture was filtered to give the expected product. This solid was dissolved in DCM (150 mL) and washed with HCI 2N (2 x 100 mL). The organic layer was dried, (Na2S04), filtered and evaporated to give the expected product (1.9 g, 24% yield) as a beige solid. The filtrate of the reaction mixture was evaporated and the residue was purified by column chromatography (Biotage, eluent: 20% to 50% EtOAc in Cyclohexane) to give the expected product intermediate 1-18, (0.77 g, 10% yield) as an orange solid
The synthetic route of 117719-17-2 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; CENTRO NACIONAL DE INVESTIGACIONES ONC&Oacgr;LOGICAS (CNIO); PASTOR FERNANDEZ, Joaquin; MARTINEZ GONZALEZ, Sonia; ALVAREZ ESCOBAR, Rosa Maria; RODRIGUEZ ARISTEGUI, Sonsoles; GONZALES CANTALAPIEDRA, Esther; HERNANDEZ HIGUERAS, Ana Isabel; VARELA BUSTO, Carmen; WO2011/36461; (2011); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem