Adding a certain compound to certain chemical reactions, such as: 21279-62-9, name is 3-Chloropyrazine-2-carboxamide, belongs to pyrazines compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 21279-62-9, Quality Control of 3-Chloropyrazine-2-carboxamide
Compound 9 is prepared by reaction of 4-chlorophenylbydrazine (3 mmol) with 3- chloropyrazine-2-carboxamide (ifi, 1 mmol) in 3 mL methanol and pyridine (1 inmol). The reaction is performed in a microwave reactor at the temperature 140 C, pressure 15 kPa and an output of 120 W during 30 miii. After completing the reaction, product 9 was isolated and purified by column chromatography on silica gel (mobile phase: hexane I ethyl acetate 1:1), yield 23%. Analytical data for compound 9: Brown crystalline solid; Mp. 155.3-156.2C; Elemental analysis calculated for C,1H10C1N5O (m.w. 263.68): 50.10% C, 3.82% H, 26.56% N; found 50.27% C, 3.72% H, 26.3 5% N; IR (ATR-Ge, cm?): 3453 (-NH-), 3202 (-CONH2), 1686 (-C=O), 1596, 1527, 1491, 1405 (pyr); ?H-NMR (300 MHz, CDCI3) oe 11.40 (IH, bs, NH), 8.45 (1H, bs, NH), 8.40 (111, d, J 2.3 Hz, H5), 8.05 (1H, d, J- 2.3 Hz, H6), 8.01 (1H, bs, NH), 7.75-7.67 (211, m, AA?, BB?, H2?, H6?), 7,40-7.32 (211, m, AA?, BE?, H3?, H5??); ?3C NMR (75 M}lz, DMSO) 8 168.9, 151.7, 145.8, 138.3, 132.9, 128.9, 127.7, 126.1, 121.4; Lipophilicity: calc. values log? = 0.34; experimental determined values log k = 0.5996.
At the same time, in my other blogs, there are other synthetic methods of this type of compound, 3-Chloropyrazine-2-carboxamide, and friends who are interested can also refer to it.
Reference:
Patent; UNIVERZITA KARLOVA V PRAZE; DOLEZAL, Martin; ZITKO, Jan; JANDOUREK, Ondrej; SERVUSOVA-VANASKOVA, Barbora; (31 pag.)WO2016/95877; (2016); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem