Electric Literature of 14508-49-7,Some common heterocyclic compound, 14508-49-7, name is 2-Chloropyrazine, molecular formula is C4H3ClN2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
Step 1: 2-hydrazinylpyrazine [0204] 2-Chloropyrazine (2.0 g, 17.5 mmol) was added dropwise to a 35% aqueous solution of hydrazine hydrate (25.8 g, 97.8 mmol) at 63-65 C, the addition rate was carefully monitored to ensure that the reaction temperature did not exceed 65 C. Following the addition, the mixture was heated to 65 C. After stirring overnight, the reaction was cooled to room temperature. The solvent was evaporated to afford the title compound as a yellow powder (1.5 g, 75%). MS (ESI) calcd for C4H6N4: 110.1; found: 111.4 [M+H]. *H NMR (400 MHz, CD3OD) delta 8.10 (d, J = 1.6 Hz, 1H), 8.00 (dd, J = 3.2, 1.6 Hz, 1H), 7.73(d, J = 3.2 Hz, 1H).
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 2-Chloropyrazine, its application will become more common.
Reference:
Patent; RUGEN HOLDINGS (CAYMAN) LIMITED; SHAPIRO, Gideon; (239 pag.)WO2016/100349; (2016); A2;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem