Extracurricular laboratory: Synthetic route of

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 33332-28-4, name is 2-Amino-6-chloropyrazine belongs to pyrazines compound, it is a common compound, a new synthetic route is introduced below. COA of Formula: C4H4ClN3

6-Chloro-5-iodo-4-ylpyrazin-2-amine To a O0C cooled stirred solution of 2-amino-6-chloropyrazine (3 g, 23 mmol) in a mixture of DMSO (90 mL) and water (2.2 mL), was added Lambda/-iodosuccinimide (5.2 g, 23 mmol) in EPO portions. After stirring for 72h, the mixture was poured into water, extracted twice with ethyl acetate, the organic layers washed with brine, dried (MgSO4) and evaporated. Flash chromatography (98:2 dichloromethane/methanol) furnished the title compound as a yellow solid (4.43 g, 76%). delta 1H-NMR (CDCI3): 7.73 (s, 1H), 4.72 (s, 2H).ESI/MS (m/e, %): 255 [(M+1) C4H3CIIN3].

The synthetic route of 33332-28-4 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; ALMIRALL PRODESFARMA, S.A.; WO2007/17096; (2007); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem