Related Products of 5521-58-4, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 5521-58-4, name is 5-Methylpyrazin-2-amine belongs to pyrazines compound, it is a common compound, a new synthetic route is introduced below.
2-Amirio-5-methylpyrazine (5.16 g, 47 itimol) was dissolved in CH2Cl2 (52 mL) , stirred and cooled to O0C under N2. To this, pyridine (4.8 mL, 59 ?unol) was added followed by phenyl chloroformate (6.2 mL, 59 mmol) , dropwise, over 15 min, causing a precipitate to form. The mixture was stirred at 0C for 1 h. Then the reaction was quenched with 0.25 M HCl (40 mL) and anhydrous ether (50 mL) , and stirred at O0C, for 30 min. The precipitate was isolated by filtration, washed with DI H2O (20 mL) and ether (2 x 25 mL) , and dried under vacuum to give the product (7.4 g) as a white fluffy powder .
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 5-Methylpyrazin-2-amine, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; ICOS CORPORATION; WO2006/105262; (2006); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem