These common heterocyclic compound, 51171-02-9, name is Methyl 3-Bromo-2-pyrazinecarboxylate, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. category: Pyrazines
A solution of 3-bromopyrazine-2-carboxylic acid methyl ester (0.10 g, 0 45 mmol), 2- t?tylsulfanylethylamine (0 29 g, 0 90 mmol), and triethylamine (0.OS mL, 0.44 mmol) in acetonitrile (5 mL) was heated to reflux for 18 h under argon. The mixture was concentrated under reduced pressure and purified by column chromatography (3:1 Hex. EtOAc), yielding 0.058 g (28%) of the desired product. 1H NMR (400 MHz1 CD2CI2) delta 7.95 (s, 1H), 8.44 (s, 1 H), 8.31 (s, 1H), 7 57.18 (m, 15H), 4 20 (s, 3H), 3.36(t, 2H), 2.50 (t, 2H).
The synthetic route of Methyl 3-Bromo-2-pyrazinecarboxylate has been constantly updated, and we look forward to future research findings.
Reference:
Patent; BAYER PHARMACEUTICALS CORPORATION; WO2006/49681; (2006); A2;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem