Reference of 138588-41-7, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 138588-41-7 name is Pyrazine-2-carboximidamide hydrochloride, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
A solution of 1-(4,5-difluoro-2-methoxy-phenyl)piperidin-4-one (250 mg, 1.03 mmol) andDMFDMA (1 mL) in acetonitrile (9 mL) was heated with stuffing at 90 C for 2 hrs. The reactionmixture was concentrated in vacuo and the residue was dissolved in EtOH (lOmL). To the solution was added pyrazine-2-carboxamidine hydrochloride (160 mg, 1.01 mmol) and potassium carbonate (279 mg, 2M2 mmol), After being heated with stirring at 90 C overnight, the reaction mixture was cooled to rt and purified by prep-HPLC to give 6-(3,4-difluoro-5-methoxy-phenyl)-2-pyrazin-2-yl-7 ,8-dihydro-5H-pyrido [4,3-d]pyrimidine (30 mg). ?H NMR (400MHz, CDC13): oe 9.75 (s, 1H), 8.81 (s, 1H), 8.78-8.70 (m, 2H), 6.50-6.38 (m, 2H), 4.42 (s, 2H), 3.95 (s, 3H), 3.65 (t, 2H), 3.31 (t, 2H). MS obsd. (ESf?) [(M+H)]: 356.
At the same time, in my other blogs, there are other synthetic methods of this type of compound, Pyrazine-2-carboximidamide hydrochloride, and friends who are interested can also refer to it.
Reference:
Patent; F. HOFFMANN-LA ROCHE AG; HOFFMANN-LA ROCHE INC.; CHENG, Zhanling; WANG, Min; YANG, Song; (208 pag.)WO2016/107832; (2016); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem