Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 23688-89-3, name is 6-Chloropyrazine-2-carboxylic acid, This compound has unique chemical properties. The synthetic route is as follows., category: Pyrazines
Intermediate 13-2: 6-chloropyrazine-2-carboxamideA solution of 6-chloro-pyrazine carboxylic acid (2.0O g, 12.62 mmol) in DMF (7 mL) was cooled to -40 0C. NMP (2.77 mL, 25.23 mmol) and isobutyl chloroformate 3.27 mL, 25.23 mmol) were added. The temperature was allowed to increase to -20 0C during 20 min and then NH4OH was added. A precipitate was rapidly formed and after 15 min it was filtered off and washed with water. Crystallization from EtOH gave the title compound (670 mg, 34 %) as light-brown needles.1H NMR (500 MHz, DMSO) delta 7.93 (br s, IH), 8.24 (br s, IH), 8.99 (s, IH), 9.12 (s, IH).
Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 23688-89-3.
Reference:
Patent; ASTRAZENECA AB; ASTRAZENECA UK LIMITED; WO2009/81195; (2009); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem