Related Products of 76537-18-3, These common heterocyclic compound, 76537-18-3, name is 3-Bromo-5-chloropyrazin-2-amine, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
First, into a three-neck flask equipped with a reflux pipe were put 5.01 g of 60 3-bromo-5-chloropyrazin-2-amine, 6.04 g of 5 2-methoxynaphthalene-1-boronic acid, 5.32 g of 6 potassium fluoride, and 86 mL of dehydrated tetrahydrofuran, and the air in the flask was replaced with nitrogen. The mixture in the flask was degassed by being stirred under reduced pressure, and then 0.44 g of 7 tris(dibenzylideneacetone)dipalladium(0) (abbreviation: Pd2(dba)3) and 3.4 mL of 8 tri-tert-butylphosphine (abbreviation: P(tBu)3) were added thereto. The mixture was stirred at 80 C. for 22 hours to be reacted. After a predetermined time elapsed, the obtained mixture was subjected to suction filtration and the filtrate was concentrated. Then, purification by silica gel column chromatography using a developing solvent (toluene:ethyl acetate=10:1) was performed, so that 5.69 g of a target pyrazine derivative (yellowish white 61 powder) was obtained in a yield of 83%. A synthesis scheme of Step 1 is shown in (e-1) below
Statistics shows that 3-Bromo-5-chloropyrazin-2-amine is playing an increasingly important role. we look forward to future research findings about 76537-18-3.
Reference:
Patent; Semiconductor Energy Laboratory Co., Ltd.; Yamaguchi, Tomoya; Yoshizumi, Hideko; Kido, Hiromitsu; Seo, Satoshi; Sasaki, Toshiki; (180 pag.)US2019/31673; (2019); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem