138588-41-7, name is Pyrazine-2-carboximidamide hydrochloride, belongs to pyrazines compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. Safety of Pyrazine-2-carboximidamide hydrochloride
A stirred mixture of 5-(bromo-p-fluorophenyl-acetyl)-1-isopropyl-3-methyl-1, 3- dihydro-benzoimidozol-2-one (8) (0.5 g, 1.23 mmol), pyrazine-2-carboxamidine hydrochloride (0.395 g, 2,49 mmol), cesium carbonate (1.22 g, 3.74 mmol) and DMF (4.0 mL) was heated to 60 C. After 1 hour, the reaction was determined to be complete by LCMS. The reaction was cooled to room temperature and diluted with water (40 mL). After stirring for 1 hour, the crude suspension was filtered and the solids were purified by flash chromatography (diethyl ether, followed by ethyl acetate to afford 40 mg of the title compound (MAPKi No.2) as a light tan solid.
The synthetic route of 138588-41-7 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; PFIZER PRODUCTS INC.?; WO2005/60967; (2005); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem