Synthetic Route of 22047-25-2, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 22047-25-2 as follows.
Weigh 1.982 g (about 0.01 mol) of bis (2-pyridine) ketone, dissolve it in 20 ml of absolute ethanol, put the solution into the flask, stir on a thermostatic heating magnetic stirrer, and weigh 1.221 g (about 0.01 mol) ) 2-Acetylpyrazine was added to the solution, and the reaction was carried out at 50 C under constant temperature and reflux for 3 hours. The solution changed from colorless and transparent to orange-yellow. After the reaction was completed, the solution was filtered, and the filtrate was left to stand to evaporate naturally. Two materials were obtained, one was orange-red rod-like crystals, and the other was massive yellow crystals. The massive yellow crystals were the target product, and the yield was about 86%.
According to the analysis of related databases, 22047-25-2, the application of this compound in the production field has become more and more popular.
Reference:
Patent; Qilu University of Technology; Tan Xuejie; Liu Shuai; Xing Dianxiang; (8 pag.)CN110606843; (2019); A;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem