Related Products of 160252-31-3, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 160252-31-3, name is 1-(5-Chloropyrazin-2-yl)ethanone belongs to pyrazines compound, it is a common compound, a new synthetic route is introduced below.
A stirred solution of 2-chloro-4-acetylpyrazine B.I (500 mg, 3.2 mmol) in EtOH (3 ml) was treated with 4-trifluoromethylaniline (619 mg, 3.8 mmol) at room temperature, followed by the addition of 4N HCl in Dioxane (0.32ml). The resulting reaction mixture was stirred at 100 C for 16 hr in a sealed tube. After consumption of the starting material (by TLC), the reaction mixture was concentrated under reduced pressure, and the resulting crude was purified by column chromatography (20% ethyl acetate/ hexane) using silica gel (60-120 mesh) to afford 430 mg (47%) of l-(5-(4-(trifluoromethyl)phenylamino)pyrazin-2-yl)ethanone B.2. 1H-NMR (DMSO- D6, 200 MHz) delta 10.51 (s, INH), 8.73 (d, J = 2 Hz, 1H), 8.31 (d, J = 2 Hz, 1H),7.99 (d, J = IO Hz, 2H), 7.72 (d, J = 8 Hz, 2H), 2.49 (s, 3H). LCMS m/z = 281.9 [M+l].
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 1-(5-Chloropyrazin-2-yl)ethanone, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; BIOGEN IDEC MA INC.; SUNESIS PHARMACEUTICALS, INC.; CHUAQUI, Claudio; COSSROW, Jennifer; DOWLING, James; GUAN, Bing; HOEMANN, Michael; ISHCHENKO, Alexey; JONES, John, Howard; KABIGTING, Lori; KUMARAVEL, Gnanasambandam; PENG, Hairuo; POWELL, Noel; RAIMUNDO, Brian; TANAKA, Hiroko; VAN VLOTEN, Kurt; VESSELS, Jeffrey; XIN, Zhili; WO2010/78408; (2010); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem