Synthetic Route of 19745-07-4,Some common heterocyclic compound, 19745-07-4, name is 2,5-Dichloropyrazine, molecular formula is C4H2Cl2N2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
To a stirred solution of (4-methyl-4-((3-(trifluoromethyl)phenyl)sulfonyl)tetrahydro-2H-pyran-2-yl)methanol (1 g, 2.9 mmol, 1 eq) in toluene (20 mL) was added 2,5-dichloro-pyrazine (0.3 mL, 2.9 mmol, 1 eq), Cs2CO3 (1.8 g, 5.9 mmol, 2 eq) and the mixture was heated to reflux for 48 h. Then the reaction mass was cooled to RT, diluted with H20 (15 mL), extracted with EtOAc (2×30 mL), washed with brine (20 mL),dried over Na2SO4 and concentrated. The crude product was purified by CC to afford 2-chloro-5-((4- methyl-4-((3-(trifluoromethyl)phenyl)sulfonyl)tetrahydro-2H-pyran-2-yl)methoxy)pyrazine (0.7 g, 53percent) as yellow gum.
The synthetic route of 19745-07-4 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; GRUeNENTHAL GMBH; SCHUNK, Stefan; REICH, Melanie; JAKOB, Florian; DAMANN, Nils; HAURAND, Michael; KLESS, Achim; ROGERS, Marc; SUTTON, Kathy; WO2015/158427; (2015); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem