These common heterocyclic compound, 113305-94-5, name is 5-Aminopyrazine-2-carbonitrile, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Formula: C5H4N4
To a suspension of 5-aminopyrazine-2-carbonitrile (211 mg, 1.74 mmol) in THF (10 mL) was added sodium hydride (116 mg, 2.90 mmol) at 0 C and stirred at ambient temperature for 1 h. Compound 305-7 (500 mg, 1.45 mmol) was added and stirred at 55 C for 2 h. After cooling to ambient temperature, the reaction mixture was quenched with ice-water and extracted with ethyl acetate. The organic layer was washed with water and brine, dried over Na2SO4 and concentrated. The crude product was purified by column chromatography (hexanes/ethyl acetate: 5/1) to afford the title compound 306-7 as a yellow solid (253 mg, 42 % yield).
The synthetic route of 5-Aminopyrazine-2-carbonitrile has been constantly updated, and we look forward to future research findings.
Reference:
Patent; PHARMAENGINE, INC.; CAI, Xiong; QIAN, Changgeng; WANG, Yanong Daniel; (98 pag.)WO2017/132928; (2017); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem