Electric Literature of 4774-14-5, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 4774-14-5, name is 2,6-Dichloropyrazine belongs to pyrazines compound, it is a common compound, a new synthetic route is introduced below.
110 mL of THF was added to 2,2,6,6-tetramethylpiperidine (3.3 mL, 20 mmol) and cooled to -78C. n-BuLi (2.5M hexane solution, 8 mL, 20 mmol) was added thereto, and the mixture was stirred at -78C for 30 minutes. 2,6-Dichloropyrazine (2.0 g, 13.4 mmol) dissolved in 20 mL was added thereto, and the mixture was stirred at -78C for90minutes. Iodomethane (3.8 mL, 60 mmol) was added thereto, and the mixture was stirred at room temperature for 3hours. Solids were removed by filtration, and the filtrate was purified by column chromatography to obtain the titlecompound (0.77 g, 35 %).1H-NMR (CDCl3) delta 8.41 (1H, s), 2.65 (3H, s)
The synthetic route of 2,6-Dichloropyrazine has been constantly updated, and we look forward to future research findings.
Reference:
Patent; LG Chem, Ltd.; KIM, Young Kwan; PARK, Sang Yun; JOO, Hyun Woo; CHOI, Eun Sil; PAEK, Seung Yup; KANG, Seung Wan; KIM, Byung Gyu; LEE, Chang Seok; KIM, Sung Wook; LEE, Sang Dae; (369 pag.)EP3239143; (2017); A2;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem