Related Products of 4949-13-7, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 4949-13-7, name is 2-Fluoropyrazine belongs to pyrazines compound, it is a common compound, a new synthetic route is introduced below.
[0220] To a mixture of (4-bromophenyl)methanamine hydrochloride (2.2 g, 9.9 mmol, (0654) 1.0 equiv) and IPA (15 mL) in a microwave vial (20 mL) were added 2-fluoropyrazine (1.1 g, 10.9 mmol, 1.1 equiv) and DIPEA (3.1 g, 23.7 mmol, 2.4 equiv). ). The vial was sealed and heated at 170 C in a microwave reactor for 4 h. The mixture was concentrated onto 10 g of Si02 and purified by silica gel chromatography (80 g column, 0-10% MeOH in DCM) to provide 1.65 g (63%) of A-(4-bromobenzyl)pyrazin-2-amine as an off-white solid. LRMS (ES) m/z 264.0 (M+H).
The synthetic route of 2-Fluoropyrazine has been constantly updated, and we look forward to future research findings.
Reference:
Patent; CYTOKINETICS, INC.; MORGAN, Bradley P.; VANDERWAL, Mark; CHUANG, Chihyuan; (0 pag.)WO2020/5888; (2020); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem